MyPeBS
is an international
EU-funded clinical study
that evaluates a new breast cancer screening strategy

MyPeBS Coordinator
Suzette Delaloge, MD, MSc, Associate Professor of Medical Oncology
Head, Breast Cancer Department, Gustave Roussy, Paris, France
Chairwoman, French UniCancer Breast interGroup UCBG

Suzette Delaloge became a specialist in medical oncology in 1997, and also obtained Master degrees in molecular biology and genetics. She spent a year in Ottawa, Canada, as a research fellow in Pr McBurney’s molecular biology lab in 1993. Dr Delaloge joined the breast cancer team at Gustave Roussy in 1999.
Dr. Delaloge has been Head of the Breast Cancer Department at Gustave Roussy, Paris, France since 2004 and currently leads a multidisciplinary team of 70 doctors, caregivers and researchers, coordinating and managing all clinical and clinical research activities.

Dr. Delaloge’s major areas of expertise and development are precision risk-based cancer prevention, therapeutic development guided by prognostic and predictive biology, and the organization of care in breast oncology. She has been investigator, principal investigator, national or international coordinator of more than 120 clinical trials over the last 20 years.

Dr. Delaloge is the author of more than 210 international peer-reviewed publications and more than 500 presentations at international conferences (Google Scholar H-Index: 53). She is chairwoman of the National French Cooperative Breast Cancer Intergroup –Unicancer (UCBG). She is a board member of the European Society of Medical Oncology (ESMO) and of the French Society of Breast Care and Breast Pathology, and a member of the American Society of Clinical Oncology (ASCO).
Dr. Delaloge is breast specialty editor for European Journal of Cancer and genetics editor for The Breast, and is also a regular reviewer of major international journals in oncology and research. She is a member of several national and international academic commissions, steering committees and scientific boards. Dr. Delaloge is finally committed to continuous teaching activities dedicated to doctors in training and medical students.

Conflict Of Interest forms

MyPeBS Global Project Manager

Camille Baron

Camille Baron, PharmD, has 20 years of experience in the field of health, mainly in the biotechnology domain. Her areas of expertise are clinical research and scientific & medical communication, which she acquired by working both with academic institutions and pharmaceutical companies (Ariad Pharmaceuticals (Cambridge, USA), Pasteur Institute, LFB Biotechnologies, Sanofi-Genzyme, Unicancer). She has developed knowledge in immunology / infectious diseases, oncology, heamostasis, rheumatology and rare metabolic diseases, as well as in project management skills.

Conflict Of Interest form

MyPeBS Clinical Trial Manager

Cécile Vissac-Sabatier

Cécile Vissac-Sabatier, PhD, is a Clinical Project Manager at UNICANCER. She has a PhD in Biology. She has over 10 years of experience in the management of clinical study first as clinical research associate and after as clinical project manager. She has worked in the public and in the private sectors on various indications in oncology (breast cancer, multiple myeloma) and non-oncology (Crohn disease, Rheumatoid Arthritis, Interstitial cystitis). She has joined UNICANCER in 2015 and she has been in charge of many clinical studies in breast cancer at national as well as international level.

Conflict Of Interest form

Principal Investigator for France

Corinne Balleyguier, MD

Dr Corinne Balleyguier, MD, PhD, is head of the radiology department at Gustave Roussy Cancer Campus, Villejuif, France. Dr Balleyguier is specialized in Women Imaging, Breast and gynaecologic Imaging. She is chair of Radiology department in Gustave Roussy. Her field of expertise and research is innovation in breast imaging, with development of new imaging techniques to improve breast cancer screening, diagnosis and treatment (contrast spectral mammography, tomosynthesis, elastography under ultrasound and MRI, laser treatment of breast tumors etc.). She is a member of the French radiological society (SFR), vice-president of the French breast Imaging society (SIFEM), the European Society of Radiology (ESR), and the European Society of Breast Imaging (EUSOBI). She is an active member elected since 2012, of the European Society of Uro-genital Radiology (ESUR), the Radiological Society of North American Radiology. She is part of the ESUR gynaecological subcommittee since 2008. She has been section editor on Woman Imaging for European Journal of Radiology since 2010. Dr Balleyguier is involved in breast Imaging committee for ECR 2012-2013-2014-2015. She was the Chairwoman of Uro-Gynecological Imaging of ECR 2010 and of breast imaging committee for ECR 2016.

Conflict Of Interest form

Founded in 2004 and headquartered in Paris, France, with a US location in Boston, MA, Predilife specialises in statistics and data mining.
Their first product was Mammorisk, an innovative software tool that can be used to estimate the risk of developing breast cancer.
MammoRisk was developed as a project funded by the ARC Foundation (France), in collaboration with the Gustave Roussy Cancer Centre (France) and the Breast Cancer Screening Consortium (US).

Stephane Ragusa

Stephane Ragusa is the founder and President of Predilife. He has been working on risk prediction models and software for prevention since 2004. He has led the project Predicancer granted by the National Agency of Research.
He graduated from Ecole Polytechnique, and from National School of Statistics and Economics (ENSAE). He holds a PhD in Molecular Biology from University Paris XI – Orsay. He is assistant professor of Statistics at University Paris VI Pierre et Marie Curie.

Conflict Of Interest form

CNGE (Collège National des Généralistes Enseignants) is the main scientific society of general medicine in France.

It brings together all the academics of the discipline (80 university, 200 associates and 8000 GP trainers) and constitutes the academic “pole” of the recognised discipline in France.

Marie-Eve Rougé Bugat, MD-PhD,

Université Paul Sabatier Toulouse III, Primary Care department, Toulouse, France
UMR 1027 (INSERM-UPS), allées Jules Guesdes, Toulouse, France
General practitioner
DESC oncology
Research CNGE member – Expert in field of cancer in primary care – Investigator of the CNGE network

Conflict Of Interest form

Paris University 13 is one of the thirteen universities that were created after the reorganization of the old Sorbonne after 1968.

It now has 24,000 students, spread across five campuses pursuing degrees or continuing education. Truly multi-disciplinary in nature, Paris University 13 is a major centre of teaching and research in the north of Paris.

Within Université Paris 13, The Institute for Interdisciplinary Research on Social Issues (Social Sciences, Policy and Health) (IRIS) is a mixed research unit associating EHESS, CNRS, Inserm, and the University of Paris 13.
IRIS brings together some 100 research holders in anthropology, sociology, history, law, political science, public health and forensic medicine.

Sandrine de Montgolfier

Sandrine de Montgolfier has been involved in many research projects in the field of empirical ethic link to health professional practices (de Montgolfier & al; Derbez & al; d’Audiffret & de Montgolfier). She also developed an expertise in the field of ethical questions raised by cancer screening (Gred and French citizen and professional consultation). She coordinated several multidisciplinary projects linked to genetic screening (INCA, ABM)

Claude Bernard Lyon 1 is a university that provides teaching for 45,000 students a year in the fields of science and technology, health and sport.

Claude Bernard Lyon 1 is part of Université de Lyon, the most important French University site outside the Paris region.
Within UoL1, the research lab Health Services and Performance Research (HeSPeR) is focused on health services performance in medical care, health promotion and prevention.

Nora Moumjid

Nora Moumjid is Senior Lecturer in Health economics and Public Health applied in cancer in Lyon 1 University, Faculty of Pharmacy. Since 1997, she works in the Comprehensive Cancer Center Léon Bérard where she leads a multidisciplinary working group composed of clinicians, socials scientists and patients on shared decision-making. She is member of the shared decision-making scientific community since the beginning and she will chair the international shared decision-making that will take place in Lyon in July 2017. She published several papers in international and national peer-reviewed journals on patients’ information and participation to the decision-making process with a focus on elicitation and risk communication methods.

Conflict Of Interest form

The ARC Foundation for cancer research is a key player in oncology research in France.
Since its creation as an association in 1962, the ARC (French acronym for: Cancer Research Association) has been a forerunner in the operation and financing of oncology research.

In 2012, in order to meet the new research challenges, the ARC decided to become a foundation, namely the ARC Foundation for Cancer Research.

Nancy Abou-Zeid, PhD.

Nancy Abou-Zeid has a PhD in Cell biology, and a training in clinical research. She has 15 years of experience in the field of oncology, both in basic and clinical research. She is Head of Translational research and innovation at the French Fondation ARC pour la recherche sur le cancer since 2011, managing a team of 3 collaborators. Her main activity is the identification of innovative projects in the field of cancer (basic, translational and clinical research, public health, epidemiology), through calls for proposals or direct partnerships with research institutes/clinical research sponsors in France or abroad. Nancy is also in charge of ARC Foundation’s scientific collaborations with French and international partners in the field of cancer research.

Conflict Of Interest form

Santé publique France (SpFrance) is the French national public health agency (around 600 staff members). Its mission is to serve the population in all aspects of public health based on scientific knowledge, data, and information. It comprises

seven scientific directorates and 15 regional units throughout the national territory. The Directorate for noncommunicable

diseases and trauma (~30 scientific staff members) covers the areas of cancers, cardiovascular diseases, mental health, nutrition, diabetes, neurodegenerative diseases, and unintentional injuries.

The cancer group comprises 10 scientific members including epidemiologists, biostatisticians, medical doctors, and data managers. Its activities include the surveillance of cancers which entails the coordination of

several data sources such as cancer registries, death certificates, health administrative databases; and the evaluation of the national cancer screening programmes.

Agnès Rogel, PhD

Agnès Rogel holds a PhD in biostatistics. She held several positions before working at Santé publique France :
She has been employed at the French University as a lecturer, at Electricite de France and at the Institute of Radiation Protection and Nuclear Safety as a biostatistician. She conducted several large epidemiological studies, mainly
cohort studies in cancer epidemiology and radiation, with main focus on breast, lung and thyroid cancer. She joined the cancer team of the French public health institute (Santé publique France) in 2008, where she first worked on cancer surveillance studies using registry or health insurance data, mainly on breast, thyroid, lung and uterine cancers. While maintaining activities and expertise on cancer surveillance, cancers attributable to lifestyles and the environment, including radiation, in 2013 she became responsible for the evaluation of breast cancer screening. Its main activities are then : the constitution of the national French breast cancer screening database, collapsing data from 99 departments; the production and analysis of the performance indicators of the national screening program; the statistical analysis of their temporal and geographical variations; the statistical analysis of the relationship between screening and social deprivation; the impact of the French breast cancer screening program on mortality.

The Centre d’Etude du Polymorphisme Humain (CEPH) was established in 1984 by Jean Dausset to promote international collaborative research in human genetics with the vision of developing individualized genomic medicine (following the model of HLA). During the subsequent 25 years, the model of international collaboration pioneered by the CEPH has been a major driver in the successful mapping and sequencing of the human genome.

Today CEPH is engaged in a variety of programs dealing with human translational genomics. CEPH is the coordinator of the GENMED LabEx funded by the French National program “Investissement d’Avenir”.

The CEPH Biobank is a center for biological resources (CRB) with a longstanding (more than 30 years) recognized experience. Historically, the CEPH Biobank was involved in the first French collections of biological samples established for genetic studies of diabetes, aging, Crohn’s disease, spondylarthropathy, neurofibromatosis but also in population genetics studies with the Human Genome Diversity Panel-CEPH (HGDP-CEPH). As of today, CEPH biobank is a key partner in the establishment of numerous cohorts funded by the French national program “Investissements d’Avenir” such as COBLAnCE, CANTO, RaDiCo and other national cohorts such as GAZEL, EPIPAGE2.

Jean-François Deleuze, Ph.D

Jean-François Deleuze is, since October 2012, both the director of the Centre National de Recherche en Génomique Humaine (CNRGH) and the scientific director of the Centre d’Etudes du Polymorphisme Humain (CEPH-Fondation Jean Dausset). JF Deleuze began his career in the pharmaceutical industry working for Rhône Poulenc Rorer and then Aventis and finally Sanofi where he established and headed the worldwide Human Genetics center of the company (40 peoples) for about 10 years. JF Deleuze has coordinated numerous international translational research collaborative projects (identification of biomarkers and therapeutic targets) in the field of the genetics of multifactorial diseases (schizophrenia, bipolar disorder, Alzheimer …) and cancer, involving academic groups but also biotechnology companies. JF Deleuze was one of the initiators/pioneers of the introduction of personalized medicine approaches in the pharmaceutical industry. In his last 2 years at Sanofi, JF Deleuze built an efficient and state of the art stem cell platform that has delivered world-class translational tools and disease models. Beside his actual leadership positions at CNRGH and CEPH, JF Deleuze is executive board member of France Génomique and heads the laboratory of Excellence (Labex) GenMed dedicated to the development of personalized genomic medicine. Recently, JF Deleuze played a key role in the development of the French Genomic medicine 2025 plan. He is in charge of heading the R&D center of the French genomic Medicine plan (CREFIX). JFD is member of several scientific boards (University Paris Sud, Vacarme project, IBISA…) and member of the editorial board of Human genetics. JFD has authored 160 publications in peer review journals and 20 patents in the field of genomic medicine. JFD’s H factor is 33.

Conflict Of Interest form

The National Human Genome Research Center (CNRGH) is a department of the CEA which main objective is to advance research of the genetics/genomics of human diseases through internal and collaborative research programs. The CNRGH is part of the Institut de Biologie François Jacob (IBFJ) within the Fundamental Research Division (DRF) of the CEA.

The CNRGH has developed a number of state-of-the-art genomics technology platforms and laboratories for the management of biological resources, for discovery of disease genes and biomarkers, and for follow-up studies using various approaches including functional genomics. A team of bioinformaticians and bioanalysts ensure data quality control, management and interpretation respectively. Key platforms include high-throughput platforms for genotyping, sequencing (WGS, WES, genes panel etc.), expression profiling (RNA-seq), DNA methylation analysis and a number of functional genomic applications (e.g. oxWG-BS, WG-BS, HiC, DNase-seq, ATAC-seq, ChIP-seq etc.). In addition there is a laboratory dedicated to technological development that performs extensive testing on the latest omics based technologies to evaluate them and determine if they are ready for routine production. The CNRGH has been extensively testing the latest long-read technologies including the Chromium platform (10X Genomics), the MinION and PromethION (Oxford Nanopore Technologies) and the Saphyr optical mapping platform (Bionano genomics).

Jean-François Deleuze, Ph.D

Jean-François Deleuze is, since October 2012, both the director of the Centre National de Recherche en Génomique Humaine (CNRGH) and the scientific director of the Centre d’Etudes du Polymorphisme Humain (CEPH-Fondation Jean Dausset). JF Deleuze began his career in the pharmaceutical industry working for Rhône Poulenc Rorer and then Aventis and finally Sanofi where he established and headed the worldwide Human Genetics center of the company (40 peoples) for about 10 years. JF Deleuze has coordinated numerous international translational research collaborative projects (identification of biomarkers and therapeutic targets) in the field of the genetics of multifactorial diseases (schizophrenia, bipolar disorder, Alzheimer …) and cancer, involving academic groups but also biotechnology companies. JF Deleuze was one of the initiators/pioneers of the introduction of personalized medicine approaches in the pharmaceutical industry. In his last 2 years at Sanofi, JF Deleuze built an efficient and state of the art stem cell platform that has delivered world-class translational tools and disease models. Beside his actual leadership positions at CNRGH and CEPH, JF Deleuze is executive board member of France Génomique and heads the laboratory of Excellence (Labex) GenMed dedicated to the development of personalized genomic medicine. Recently, JF Deleuze played a key role in the development of the French Genomic medicine 2025 plan. He is in charge of heading the R&D center of the French genomic Medicine plan (CREFIX). JFD is member of several scientific boards (University Paris Sud, Vacarme project, IBISA…) and member of the editorial board of Human genetics. JFD has authored 160 publications in peer review journals and 20 patents in the field of genomic medicine. JFD’s H factor is 33.

Conflict Of Interest form

Assuta is Israel’s largest and leading group of private medical services centres, comprising eleven clinics and five hospitals across Israel. More than 50% of all services are provided to publicly-insured patients. Assuta provides innovative surgeries and diagnostic procedures in all fields of medicine.

Assuta Imaging Centres offer a broad range of services and tests nationwide.

Assuta is one of the founders of breast screening imaging centres, providing this service to the Israeli population for the last 20 years.

Michal Guindy, M.D. MPA

Michal Guindy received her MD from Ben-Gurion University Medical School, Beer Sheva, Israel in 1982. Dr Guindy specialized in radiology and is still a practicing radiologist (breast). In 2001 she earned a MPA from the Kennedy School of Government – Harvard University, Boston, Massachusetts USA. At Maccabi Healthcare Services (HMO) Dr Guindy held several management positions during the years 1998-2014. She chaired the Risk Management and Patient Safety Department from 2003 through 2009. From 2009 through 2011 Dr Guindy was Head of Central Services, where she was responsible for radiology telemedicine, laboratories including the pathology lab, pharmacies and call centers. During the years 2011- 2014 Dr Guindy served as Medical Director of the Central district, Israel, a position responsible for medical services provided to 250,000 people.Since 2014 Dr Guindy has been Medical Director of Imaging at Assuta Medical Centers. She is responsible for running the seven imaging centers across Israel producing over 600,000 studies annually.
Her academic activities include coordinator of Patient Safety Implementation Program (WHO initiative) in Sackler School of Medicine, Tel Aviv University. Since 2013 Dr. Guindy has been involved in multiple Big Data research projects, particularly in the field of radiology.

Conflict Of Interest form

Maccabi Healthcare Services, a non-profit organization and the mother company of Assuta Medical Centers, is the second largest Health Plan in Israel with 1.9 million members. It provides comprehensive health care services to its members. Most outpatient visits lab tests and the interface and communication with patients is performed by the Health Plan via its doctors and staff, providing services throughout the country via hundreds of specialized outpatient clinics. Maccabi is also responsible for implementing the National Breast Screening program for its members. Assuta Medical Centers perform the radiological imaging for most of Maccabi’s members.

After recruitment, which will be performed by Assuta, Maccabi will transmit coordination of instructions to the patient’s file and the relevant parties.

The Local Health Authority (AUSL) of Reggio Emilia is the institution that administer the National Health Service in the

Reggio Emilia province. It provides directly in-patients, out-patients, primary and preventive care; it also buys from other private and public hospitals and clinics for all the citizens residents in the province.

It works for the protection and the improvement of public health, health promotion and the reduction of health inequalities and access to services.

Paolo Giorgi Rossi, PhD, MSc

Dr Paolo Giorgi Rossi obtained the MSc in Molecular Biology in 1994 and Ph.D. in Cellular and Animal Biology in 1998 at the University of Pavia (Pavia, Italy). Since 1998, he has been working at the Agency for Public Health of Lazio, Rome, Italy, where he directed the Health Technology Assessment Service from 2006 to 2012. Now he is the director of the Epidemiology Service in the Reggio Emilia Local Health Authority and Research Hospital (AUSL – IRCCS). His principal interest is the evaluation of Public Health interventions and particularly cancer screening. He is principal investigator of several independent epidemiological studies and screening trials. He is author or co-author of more than 250 publications indexed in PubMed and more than 50 monographs and book chapters. He is has been the president of the Italian Cervical Cancer Screening Group, the scientific society of the cervical cancer screening in Italy and member of the coordinating committee of the Italian Mammographic Screening Group. He collaborates with the EUREGHA (European Regional Health Authorities Association) in the screening working group.
In 2006 he joined the didactic committee of the Ulysses International Master in HTA.

Conflict Of Interest form

The Centre for Cancer Epidemiology and Prevention in the Piedmont Region (CPO) at the AOU Città della Salute e
della Scienza, Torino, is active in cancer registration, primary cancer prevention, cancer screening programmes, monitoring the quality of care for cancer patients and research on cancer aetiology, within the Regional Health System.

In May 2014 CPO was designated as WHO Collaborative Centre for cancer early detection and screening, representing the only European WHO Collaborative Centre in this field.

Livia Giordano
Senior epidemiologist at the Unit of Epidemiology, Screening and Cancer Registry – CPO of AOU Città della Salute e della Scienza di Torino.

• 1991-2001: Epidemiologist at Local Health Agency n. 1 – Turin.
• Since 2002: Epidemiologist c/o AOU Città della Salute e della Scienza di Torino.
• 1989- 2000: Member of the Oncology Committee of the Piedmont Region.
• 2000-2010: Member of the Faculty of the post-doctoral School of Oncology, University of Turin 2003-2011: Member of the Anti-Tobacco Board – Piedmont Region
• 2009-2015: President of the Italian Group for mammography screening (GISMa)
• Since 1991: Member of the Faculty of the Italian School of Senology
• Since 1993: Member of the School of Public Health, University of Turin.
• Since 2008: Member of the Editorial Board of the journal ‘Epidemiologia e Prevenzione’
• Since 2012 – Member of the Scientific Committee of Europa Donna
• Since 2015: chapter co-editor on Communication of the European Breast Guidelines promoted by ECIBC

Research fields: Breast and cervical cancer screening organisation and evaluation, randomised trial on cancer screening compliance, communications and psychological aspects in secondary cancer prevention interventions, cancer screening by immigrant and minority women; cancer screening in developing countries and in low-resource settings; smoking prevention and control; cancer screening and healthy lifestyle promotion interventions (diet, physical activity and tobacco consumption).

Conflict Of Interest form

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, IRST IRCCS, is a medical Institutions of excellence, particularly dedicated to biomedical and health system research with its focus on cancer. The Institute was created by a public-private partnership between public Regional Health authorities, a non-profit private organisation, and local banking foundations.

IRST IRCCS is fully integrated within the Public Health system in a north-eastern area of Italy with more than 10.000.000 of resident population.

Fabio Falcini, MD

Fabio Falcini graduated in Medicine and Surgery at the Medical School University of Bologna, specialization in Oncology, haematology and radiology. Member of the Ethical Committee of Area Vasta Romagna (2007-2011); Appointed Coordinator of screening programme for prevention of colorectal tumor in the Area Vasta Romagna-Programma regionale Screening from Dec 2004;Director of Oncological Prevention Unit of Forlì (AUSL Romagna);Director of the Romagna Cancer Registry (IRST);Director of Onco-Hematology Department at IRST; Coordinator of 3 screening programs (breast and uterus since March 1995; colorectal cancer in December 2004, at Ospedale di Forlì). Vicesecretary of Associazione Italiana Registri Tumori (AIRTUM) 2009-2013; Member of board for the personnel training (BDF) 2002-2007 in AUSL Forlì;Deputy President Lega Italiana per la Lotta contro i Tumori (LILT) from july 2014;

Coordinator IOR Medical Scientific Committee from June 2014. Coordinator and teacher in courses on clinical and instrumental breast cancer diagnostics organized by the Forlì School of Biomedical Sciences and Oncology 1992-1995; member (1997) of the Ministry of Health working group, Department of Planning, for the translation of ICD-9-CM classification; 1996-2001 coordinator of the National Research Council (CNR) Strategic Project Robotics in Surgery; Teacher at the Postgraduate School of Oncology, University of Ferrara for the topics “Epidemiology, Prevention and Early Diagnosis of malignant tumors”(ongoing).

Conflict Of Interest form

Institute for Study and Cancer Prevention is a scientific institute of Tuscany Regional Health System. It is involved in
primary and secondary preventive oncology research. Within the Institute screening for breast, cervical and colorectal cancer is ongoing since the 1980s and high skilled competences in epidemiology, breast radiology, gynaecology and gastroenterology are represented.

The Institute was appointed for both National Screening Monitoring Centre (ONS) and Regional Reference Centre for Preventive Oncology (CRRPO).

Paola Mantellini, MD

Paola Mantellini is an oncologist, Director of ISPRO Screening Unit and Coordinator of Regional Reference Centre for Preventive Oncology. She is involved in quality evaluation of organized screening programs through indicators monitoring, clinical auditing (site visits), elaboration and update of screening recommendation at a regional level. She is also involved in coordination of the Tailored Breast Screening Trial and she had developed experience in organizational analysis for Activity Based Costing methodology

Conflict Of Interest form

Henricus J de Koning
Professor of Public Health & Screening Evaluation in the Department of Public Health of the Erasmus Medical Center in Rotterdam.

Professor Henricus (Harry) J de Koning worked as Researcher and Assistant Professor in the Department of Public Health of the Erasmus University in Rotterdam (1987-1999). He became Associate Professor in 1999 and in 2008 he was appointed Professor of Public Health & Screening Evaluation in the same department. He was also Senior Associate in the Department of Health Policy and Management at the Johns Hopkins Bloomberg School of Public Health (2011-2012). Since 2011 he has been a Member of the Medical Advisory Board of the Royal Netherlands Academy of Arts and Sciences (KNAW).
His major scientific contributions are in the areas of

• Designing, running and evaluating large-scale multidisciplinary population-based randomized controlled screening trials to establish the efficacy of screening;
• Evaluating active international screening programs and tests to establish effectiveness;
• Guiding public health policies using predictions of favorable and unfavorable effects and the cost of screening, based on micro-simulation modelling of the natural history of disease, and cost-effectiveness and cost-utility analyses.

See also:

http://www.erasmusmc.nl/public-health/organization/our-associate-professors-page/h-de-koning/

http://survey.erasmusmc.nl/pwp/hdekoning

Conflict Of Interest form

University of California, San Francisco (UCSF) is the only campus in the 10-campus University of California system that is exclusively focused on the health sciences, with top-ranked programs in medicine, nursing, pharmacy, dentistry, basic science, social science and global health.

UCSF is the top public recipient of funding from the National Institutes of Health (NIH) in the United States.

The Athena Breast Health Network, headquartered at UCSF, is a network of the 5 University of California medical centres and Sanford Health, one of the largest rural health networks in the country.

Laura Esserman, MD

Dr. Esserman has a wealth of experience overseeing innovative, large-scale clinical trials. She is co-principal investigator of the I-SPY platform trial taking place at institutions across the United States. I-SPY is a biomarker-rich, adaptive, multi-agent clinical trial platform that introduces administrative and statistical efficiencies, and capitalizes on the availability of a near-term surrogate endpoint to speed the phase II development of new agents for neoadjuvant treatment of advanced breast cancer. To date, 10 agents have been screened in the trial, with a number ‘graduating’ to phase III clinical trials.
In 2015, under Dr. Esserman’s direction, Athena Network was awarded a grant from the US “Patient Centered Outcomes Research Institute” to conduct a large-scale comparative effectiveness trial of risk-based screening for breast cancer versus annual screening (the US standard of care). WISDOM has assembled a truly multidisciplinary team and demonstrated its significant expertise in a vast array of specialties required to undertake a trial such as WISDOM or MyPeBS, including: mammography and standardization of imaging, genetic screening and counselling, modelling breast cancer risk and polygenic risk scores, development of clinical decision tools based on cancer risk, electronic survey tools and instruments and their integration with case report forms, measurement of the psychological impacts of screening/diagnoses, and other operational components required for trial implementation. The 100,000 patient WISDOM study, a companion study to the current proposal, opened in September 2016 and is currently enrolling.

Conflict Of Interest form

Principal Investigator for UK
Prof Fiona Gilbert

Professor of Radiology, Head of Department of Radiology at the University of Cambridge for 5 years and prior to that at the University of Aberdeen since 1996. She is an expert in all modalities of clinical breast imaging, has more than 30 years experience in breast screening, previously as Clinical Director of screening in the Northeast of Scotland. She has an extensive research track record in assessing novel imaging techniques (Multispectral OptoAcoustic imaging, DBT, CESM, PET MRI), has experience in running multicentre imaging trials, undertaking systematic reviews. She has run several large scale clinical imaging studies in breast screening (TOMMY trial 9,000 women; CADET II 30,000 women; CADET I 10,000 women). She participated in MARIBS MRI screening trial of high risk screening which influenced practice in the UK and the IBIS, the tamoxifen prevention trial. She is chair of the UK National Cancer Research Institute Imaging Advisory Group.

Conflict Of Interest form

Prof Gareth Evans

Professor Evans has established a national and international reputation in clinical and research aspects of cancer genetics, particularly in neurofibromatosis and breast cancer.
He has published 715 peer reviewed research publications; 265 as first or senior author. He has published over 110 reviews and chapters and has had a book published by Oxford University Press on familial cancer. He has an ISI web of knowledge H-index of 97 and google scholar of 131 having only published his first article in 1990. In the last 7 years he has raised over £45 million in grants for multicentre and local studies – approximately £38 million to Manchester. He is Chief Investigator on two NIHR program grants (2009-2014-£1.59 million) (2017-2020-£1million) on breast cancer risk prediction and also has an NIHR RfPB grant as CI (2011).  He as supervised 13 successful doctoral theses and is currently supervising five. He has led a successful bid for a Nationally funded NF2 service (£7.5 million pa) that started in 2010 and is involved in the national complex NF1 service. He is overall cancer lead (3 themes) and Cancer Prevention Early detection theme lead on the successful all Manchester NIHR Biomedical research centre bid (2017-2022-£28.5million). He is lead clinician on the NICE familial breast cancer guideline group and until recently a trustee of Breast Cancer Now and the Neuro Foundation. He is on the editorial board of JNCI and is a board member of the Science Strategy Committee of Breast Cancer Now.

Conflict Of Interest form

The University of Nottingham (UoN) has considerable expertise in breast cancer screening; hosting the Nottingham Breast Institute and is also home to the UK’s national breast pathology External quality assessment (EQA) scheme. In 2019, staff of the Applied Vision Research Centre (AVRC), Loughborough University, moved to join UoN. These staff embody the leading European centre for the monitoring and assessment of the performance of radiologists in interpreting medical images. Staff have been involved in medical imaging for over 40 years and developed the PERFORMS scheme which is a world first in monitoring the skills of breast screening radiologists. The UoN is involved in several national projects concerning breast cancer as well as other cancers including prostate and lung cancer.

Yan Chen, BSc PhD HonMRCR

Director of the Applied Vision Research Centre. Dr Chen is a computer scientist and a leading international scientist in the field of medical imaging perception and specialises in women’s health, particularly breast cancer. She leads the PERFORMS self-assessment scheme in breast cancer (a major UK national research project which is funded at over €1.2m every three years), as well as other imaging research in radiology and surgery. She has been awarded honorary membership of the Royal College of Radiologists for her radiological research.

Conflict Of Interest form

Role in MyPeBS

Within MyPeBS’s Workpackage 3, the UoN will lead in the quality assessment of the trial radiologists to ensure that they all are of an equivalent international standard. The UoN will deploy the PERFORMS self-assessment scheme across all radiologists and regularly assess their breast cancer identification skills using difficult test breast screening case sets of known outcome. The UoN has numerous appropriate test sets of challenging and difficult screening cases which it can use and which are based on many years of experience with the UK Breast Screening Programme

Queen Mary University of London is one of the UK’s leading research-focused higher education institutions. With 21,187 students and 4,000 staff, it is one of the biggest University of London colleges.
It encompasses Barts and the London School of Medicine and Dentistry.
The Centre for Cancer Prevention (CCP) is housed in the Wolfson Institute of Preventive Medicine within the School of Medicine and Dentistry.
The CCP is a leading research centre in primary prevention of and screening for cancer.

Stephen W. Duffy

Stephen Duffy is a statistician by training, educated at the University of Edinburgh and Imperial College, London. He has worked in the UK, Singapore, France, Sweden and Russia. He is the Director of the Department of Health’s Policy Research Unit in Cancer Awareness, Screening and Early Diagnosis.
For the last three decades, his research has been mainly in cancer epidemiology, prevention and screening. He worked on the pioneering Swedish Two-County Trial of breast cancer screening, on which the UK’s national breast screening programme was based. Since then, he has taken a major role in a number of other trials of cancer screening, in breast, colorectal and lung cancer. These include the UK Trial of Flexible Sigmoidoscopy whose results changed national policy within weeks of publication, and the FH01 study of annual mammography in young women at enhanced familial risk of breast cancer, which contributed to the NICE guidelines on breast cancer risk management.
More recently his research has focussed on behavioural aspects of screening, including trials of reminders, second timed appointments and out-of-hours appointments in breast cancer screening, and trials of augmented invitations and reminders, and primary care endorsement in colorectal cancer screening. He is a screening editor on the EU Guidelines Development Group for breast cancer screening and diagnosis, and a member of the UK’s National Screening Committee.

Conflict Of Interest form

Independent Cancer Patients’ Voice (ICPV) is a patient advocate group independent of established UK cancer charities and aware of the value of medical research to both public health and to the national economy.

The aim of ICPV is to improve existing treatments for every cancer patient and develop new treatments by bringing the patients’ voice into clinical research.

Debbie Keatley, patients’ representative​

Debbie Keatley who has experienced cancer as a patient and carer, as well as other long-term conditions, is passionate about the rights of patients to be involved as equal partners in decisions that affect their treatment and care. Debbie’s ambition is for patients and the public across the UK to feel confident that they can access and understand the information in their health records and can make informed choices about how it’s used in their direct care and in research.

Debbie has worked in the private sector in international finance, in the voluntary sector in IT and training and development, in the public sector in further education and more recently as a policy adviser.

Debbie is now involved in an advisory capacity with many organisations and movements who rely on health data and recognise its importance in research to improve outcomes for patients. This includes useMYdata, Independent Cancer Patient Voice, Cancer Research UK’s Population and Clinical Research committees, National Cancer Research Institute’s Consumer Forum, and the Clinical Evaluations and Trials committee at National Institute for Health Research’s Health Technology Assessment programme.

Living in Belfast, Debbie is also a member of Northern Ireland Cancer Research Consumer Forum and the Council of Northern Ireland Cancer Registry. She is also involved in patient and public involvement in clinical studies from international to local level.